AMYLOID BETA-PEPTIDE (25-35) (HUMAN)

中文名	β-淀粉状蛋白 (25-35)
英文名	amyloid B-protein fragment 25-35
别名	Β淀粉样蛋白25-35 Β-淀粉状蛋白25-35 淀粉样Β-蛋白片段25-35 β-淀粉状蛋白 (25-35) BETA-淀粉样蛋白片断25-35 BETA-类淀粉蛋白肽(25-35) AMYLOID Β-PROTEIN FRAGMENT 25-35 Β-淀粉状蛋白25-35
英文别名	Β-AMYLOID (25-35) Amyloid beta-peptide(25-35) AMYLOID BETA-PROTEIN (25-35) amyloid B-protein fragment 25-35 AMYLOID BETA-PROTEIN FRAGMENT 25-35 AMYLOID BETA-PEPTIDE (25-35) (HUMAN) AMYLOID-BETA PROTEIN (25-35), HUMAN, MOUSE, RAT H-GLY-SER-ASN-LYS-GLY-ALA-ILE-ILE-GLY-LEU-MET-OH Amyloid beta-Protein (25-35) trifluoroacetate salt AMYLOID BETA-PROTEIN (HUMAN, 25-35) TRIFLUOROACETATE Amyloid Beta-Protein (Human, 25-35) Trifluoroacetate
CAS	131602-53-4
化学式	C45H81N13O14S
分子量	1060.27
InChI	InChI=1/C45H81N13O14S/c1-9-24(5)36(43(69)50-21-35(63)52-29(17-23(3)4)40(66)55-28(45(71)72)14-16-73-8)58-44(70)37(25(6)10-2)57-38(64)26(7)51-34(62)20-49-39(65)27(13-11-12-15-46)54-41(67)30(18-32(48)60)56-42(68)31(22-59)53-33(61)19-47/h23-31,36-37,59H,9-22,46-47H2,1-8H3,(H2,48,60)(H,49,65)(H,50,69)(H,51,62)(H,52,63)(H,53,61)(H,54,67)(H,55,66)(H,56,68)(H,57,64)(H,58,70)(H,71,72)/t24-,25-,26-,27-,28-,29-,30-,31-,36-,37-/m0/s1
InChIKey	WIHBNMPFWRHGDF-SLVFWPMISA-N
密度	1.248±0.06 g/cm3(Predicted)
沸点	1517.3±65.0 °C(Predicted)
闪点	871.453°C
水溶性	Soluble in water.
蒸汽压	0mmHg at 25°C
折射率	1.544
酸度系数	3.24±0.10(Predicted)
存储条件	-20°C
外观	冻干。
MDL号	MFCD00133076
体外研究	The amino acid sequence of Aβ(25-35) peptide is NH 2 -Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-COOH, where the first Gly represents the amino acid 25 and the last Met represents the amino acid 35. Amyloid beta-peptide(25-35) is also investigated in gel state for the first time. Comparative studies are also carried out using vibrational absorption and ECD. The conformational preference of Aβ(25-35) peptide film is also investigated using vibrational absorption and VCD spectroscopy. Amyloid beta-peptide(25-35) induces apoptotic effects on isolated brain mitochondria and the redox state of methionine-35, plays a key role in the induction of programmed cellular death pathways and toxic events. β-Amyloid Aggregation Guidelines (Following is our recommended protocol. This protocol only provides a guideline, and should be modified according to your specific needs). 1. Solid Aβ peptide was dissolved in cold hexafluoro-2-propanol (HFIP). The peptide was incubated at room temperature for at least 1h to establish monomerization and randomization of structure. 2. The HFIP was removed by evaporation, and the resulting peptide was stored as a film at -20 or -80 ℃. 3. The resulting film was dissolved in anhydrous DMSO at 5 mM and then diluted into the appropriate concentration and buffer (serum- and phenol red-free culture medium) with vortexing. 4. Next, the solution was age 48h at 4-8 ℃. The sample was then centrifuged at 14000g for 10 min at 4-8 ℃; the soluble oligomers were in the supernatant. The supernatant was diluted 10-200-fold for experiments. Methods vary depends on the downstream applications.
体内研究	Rats are injected with Aβ25–35 peptide intracerebroventricularly and compound Danshen (CDS) are subsequently administered once daily for 23 days. Rats’ behavior is monitored using Morris water maze and passive avoidance. Real time PCR and Western blotting are used in determining amyloid precursor protein (APP), β-site APP cleaved enzyme-1(BACE1), Presenilin-1 (PS1), Insulin-degrading enzyme (IDE) and neprilysin (NEP) in hippocampus. The Alzheimer' s disease (AD) model group present with spatial learning and memory impairments. CDS and donepezil administration significantly ameliorate the Aβ25–35 peptide-induced memory impairment in both Morris water maze (P [3] .
WGK Germany	3
RTECS	BU7435200
参考资料展开查看	1. [IF=5.118] Xin Wang et al."Simultaneous Inhibitory Effects of All-Trans Astaxanthin on Acetylcholinesterase and Oxidative Stress."Mar Drugs. 2022 Apr;20(4):247

AMYLOID BETA-PEPTIDE (25-35) (HUMAN) - 介绍

氨基酸序列 Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met

最后更新：2022-10-16 17:13:19

AMYLOID BETA-PEPTIDE (25-35) (HUMAN) - 简介

β-淀粉样蛋白 (25-35)，也被称为Aβ蛋白 (25-35)，是一种在阿尔茨海默病的神经纤维缠结中发现的蛋白质片段。它是由β-淀粉样蛋白 (β-amyloid protein) 切割得到的，长度为25至35个氨基酸残基。

其性质，β-淀粉样蛋白 (25-35) 可以形成富含β-折叠的聚集体，导致神经纤维缠结，损害神经元的功能。这被认为是阿尔茨海默病的重要病理特征之一。

β-淀粉样蛋白 (25-35) 可以通过化学合成或者酶解β-淀粉样蛋白 (β-amyloid protein) 得到。在化学合成中，该蛋白片段可以通过合成肽技术来合成。酶解法可以通过使用适当的酶对β-淀粉样蛋白进行消化来得到。

最后更新：2024-04-09 21:54:55

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